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2021 San Francisco 49ers Regular Season Schedule

The 2021 San Francisco 49ers schedule consist of playing each opponent twice in their own division and playing each opponent once in AFC South and NFC North divisions. The 49ers will also play one opponent at home from the NFC South and one opponent on the road from the NFC East.

2021 San Francisco 49ers Opponents
HOME AWAY
Green Bay Packers Chicago Bears
Minnesota Vikings Detroit Lions
Houston Texans Jacksonville Jaguars
Indianapolis Colts Tennessee Titans
NFC South Opponent NFC East Opponent
Arizona Cardinals Arizona Cardinals
Los Angeles Rams Los Angeles Rams
Seattle Seahawks Seattle Seahawks

San Francisco 49ers TV Schedule

Week Date Game Time ET TV
1 Sun, 9/12 - - -
2 Sun, 9/19 - - -
3 Sun, 9/26 - - -
4 Sun, 10/3 - - -
5 Sun, 10/10 - - -
6 Sun, 10/17 - - -
7 Sun, 10/24 - - -
8 Sun, 10/31 - - -
9 Sun, 11/7 - - -
10 Sun, 11/14 - - -
11 Sun, 11/21 - - -
12 Sun, 11/28 - - -
13 Sun, 12/5 - - -
14 Sun, 12/12 - - -
15 Sun, 12/19 - - -
16 Sun, 12/26 - - -
17 Sun, 1/2 - - -

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