The 2021 San Francisco 49ers schedule consist of playing each opponent twice in their own division and playing each opponent once in AFC South and NFC North divisions. The 49ers will also play one opponent at home from the NFC South and one opponent on the road from the NFC East.
HOME | AWAY |
---|---|
Green Bay Packers | Chicago Bears |
Minnesota Vikings | Detroit Lions |
Houston Texans | Jacksonville Jaguars |
Indianapolis Colts | Tennessee Titans |
Atlanta Falcons | Philadelphia Eagles |
Arizona Cardinals | Arizona Cardinals |
Los Angeles Rams | Los Angeles Rams |
Seattle Seahawks | Seattle Seahawks |